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Sepsis, severe burns, and postoperative critical illness differ substantially in metabolic stress, muscle loss, and vulnerability of organ dysfunction, and future trials should therefore compare standard versus higher protein intakes and early versus delayed initiation strategies across distinct phases of illness, with endpoints including mortality, organ function, skeletal muscle outcomes, and functional recovery (5255, 67, 92, 94, 95, 127)

FDA approvals in the second half of 2025 continued the rapid expansion of immunotherapy across solid tumors and hematologic malignancies, with a strong emphasis on earlier disease settings, perioperative strategies, and next-generation immune platforms such as CAR T cells and bispecific antibodies

Zuo et al [15] found that patients with paroxysmal and persistent AF have distinct gut microbiota and metabolite profiles compared to non-AF individuals[15]

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In case of SARS-CoV2, conceptually, Broad spectrum antiviral agents (BSAA) are more advantageous as repurposing agents as they targets two or more viral families